Antihistamines do not inhibit the flare induced by the intradermal injection of autologous plasma in chronic urticaria patients
Articolo
Data di Pubblicazione:
2009
Citazione:
Antihistamines do not inhibit the flare induced by the intradermal injection of autologous plasma in chronic urticaria patients / R. Asero, A. Tedeschi, M. Lorini, M. Cugno. - In: EUROPEAN ANNALS OF ALLERGY AND CLINICAL IMMUNOLOGY. - ISSN 1764-1489. - 41:6(2009), pp. 181-186.
Abstract:
Background : there is some evidence suggesting that factors other than autoantibodies to FceRI or IgE and histamine released from mast cells may play a role in skin autoreactivity that characterizes many patients with chronic urticaria (CU) and, possibly, in the pathogenesis of this disease. Objective : the effect of antihistamine treatment on autologous plasma skin test (APST) in patients with CU was assessed. Methods : 24 patients with CU underwent autologous plasma skin test (APST) as well as SPT with histamine 10 mg/ml while taking antihistamines. In 6 cases the same tests had been carried out also before the start of antihistamine treatment. Plasma levels of Ddimer, prothrombin F1+2 fragment, and vascular endothelial growth factor (VEGF)
were measured in 21 patients. Results: 21/24 (87%) patients showed a large flare on APST while taking antihistamines while the skin reaction to histamine 10 mg/ml was abolished or negligible. Little difference in the autologous plasma-induced flare was seen before and after the start of cetirizine therapy in 6 cases, whereas the drug
exerted a marked effect on the histamine SPT as well as on the autologous plasma-induced
wheal. The APST-induced flare was not associated with patients’ response to antihistamine. Plasma levels of VEGF, prothrombin F 1+2 fragment, and D-dimer
were increased in plasmas from 8, 9, and 2 patients, respectively. Conclusions : factors
other than histamine are probably involved in the flare following APST in CU; such factors might play a pathogenic role particularly in patients not responding to
standard antihistamine treatments
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Autoreactivity; Chronic urticaria; Histamine; Skin testing
Elenco autori:
R. Asero, A. Tedeschi, M. Lorini, M. Cugno
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