Data di Pubblicazione:
2009
Citazione:
Pharmacokinetics and efficacy of teicoplanin against intramammary infections in sheep / C. Naccari, P.P. Niutta, D. Trombetta, A. De Domenico, F. Pizzimenti, P. Cagnardi, S. Carli, F. Naccari. - In: THE VETERINARY RECORD. - ISSN 0042-4900. - 165:1(2009 Jul), pp. 19-22. [10.1136/vetrec.165.1.19]
Abstract:
The pharmacokinetics of teicoplanin were evaluated in 10 healthy sheep. After intravenous injection it showed monophasic behaviour, with a short mean (sd) elimination half-life (5 [0·24] hours). After intramuscular injection its bioavailability was 100 per cent but it was absorbed slowly; its elimination half-life was satisfactorily slow (9·23 [0·74] hours). Its efficacy was evaluated in 26 crossbreed sheep with milk positive to strains of Staphylococcus aureus, coagulase-negative staphylococci and Streptococcus agalactiae, and clinical signs of disease. In 19 of them a single intramuscular dose of 6 mg/kg bodyweight resulted in a complete resolution of the clinical signs, and no microorganisms were detected in milk by the fifth day; in the other seven sheep, with more severe intramammary infections, three consecutive daily intramuscular doses of 6 mg/kg bodyweight were necessary. There were no local or systemic side effects and no relapses during 30 days after the treatments in any of the sheep.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
C. Naccari, P.P. Niutta, D. Trombetta, A. De Domenico, F. Pizzimenti, P. Cagnardi, S. Carli, F. Naccari
Link alla scheda completa: