Interleukin-1 beta and interferon-gamma induce proliferation and apoptosis in cultured Schwann cells
Articolo
Data di Pubblicazione:
2002
Citazione:
Interleukin-1 beta and interferon-gamma induce proliferation and apoptosis in cultured Schwann cells / G. Conti, A. De Pol, E. Scarpini, F. Vaccina, M. De Riz, P. Baron, M. Tiriticco, G. Scarlato. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - 124:1-2(2002), pp. 29-35.
Abstract:
This study reports that in Schwann cell tissue culture the administration of the two pro-inflammatory cytokines, interleukin-1 beta (IL-1 beta) and interferon-gamma (IFN-gamma), at different dosages, singly or in combination, can induce apoptosis and/or mitosis.Schwann cell apoptosis was maximal within 24 h of stimulation with 50 U/ml of IFN-gamma, while proliferation was at its peak within 24 h with 10 U/ml IL-1 beta, and both processes decreased progressively by 48 and 72 h. Moreover, the combination of the two cytokines did not show any synergistic effect. These data can be interpreted as a possible involvement of pro-inflammatory cytokines not only in myelin disruption but also in promoting remyelination.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
G. Conti, A. De Pol, E. Scarpini, F. Vaccina, M. De Riz, P. Baron, M. Tiriticco, G. Scarlato
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