Inhibition of NF-kB and metalloproteinase-9 expression and secretion by parthenolide derivatives
Articolo
Data di Pubblicazione:
2009
Citazione:
Inhibition of NF-kB and metalloproteinase-9 expression and secretion by parthenolide derivatives / M. Dell'Agli, G. Galli, E.A. Bosisio, M. D'Ambrosio. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 19:7(2009), pp. 1858-1860.
Abstract:
Semisynthetic derivatives of parthenolide (1) were tested on NF-kB driven transcription and metalloproteinase-
9 (MMP-9) expression and secretion. The four membered ring compounds 5 and 6, obtained by
acidic treatment of 1, exhibited a higher activity with respect to 1 in all the biological assays. Then an
increased ability of the 5 and 6 to inhibit NF-kB driven transcription may lead to a down-regulation of MMP-9 expression and secretion. This work provides new details about the structural requisites for NF-kB inhibition
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
M. Dell'Agli, G. Galli, E.A. Bosisio, M. D'Ambrosio
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