Interferon-gamma and granulocyte-macrophage colony stimulating factor therapy in three patients with pulmonary aspergillosis
Articolo
Data di Pubblicazione:
2008
Citazione:
Interferon-gamma and granulocyte-macrophage colony stimulating factor therapy in three patients with pulmonary aspergillosis / A. Bandera, D. Trabattoni, G. Ferrario, M. Cesari, F. Franzetti, M. Clerici, A. Gori. - In: INFECTION. - ISSN 0300-8126. - 36:4(2008 Aug), pp. 368-373.
Abstract:
An immune response mediated by type 2 cytokines is thought to contribute to the development and unfavorable outcome of aspergillosis. Adjuvant therapy with interferon-gamma (IFN-gamma) and granulocyte-macrophage colony stimulating factor (GM-CSF) was added to antifungal treatment in three nonneutropenic patients (one HIV-positive and two HIV-negative patients) with culture proven aspergillosis refractory to classical antifungal therapy. Clinical improvement was observed concomitantly with an increase in peripheral blood leukocyte proliferation and type 1 cytokines production. Our findings suggest an association between the improvement in type 1 cytokine production observed during IFN-gamma and GM-CSF administration and a better control of Aspergillus infection in patients with progressive disease despite adequate antifungal therapy.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
A. Bandera, D. Trabattoni, G. Ferrario, M. Cesari, F. Franzetti, M. Clerici, A. Gori
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