Data di Pubblicazione:
2005
Citazione:
Synthesis and antimalarial activities of some furoxan sulfones and related furazans / U. Galli, L. Lazzarato, M. Bertinaria, G. Sorba, A. Gasco, S. Parapini, D. Taramelli. - In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0223-5234. - 40:12(2005 Jun), pp. 1335-1340. [10.1016/j.ejmech.2005.05.001]
Abstract:
Furoxan derivatives bearing a sulfone moiety at position 3 or 4 were synthesized and tested for their antimalarial action on the chloroquine-sensitive D10 and the chloroquine-resistent W2 strains of Plasmodium falciparum. The furazan analogues were considered for comparison. The most active compounds were the products in which the –SO2R groups are at the 3-position of the furoxan system. These latter substances displayed an antimalarial activity in the μM range, possibly related in part to their ability to release NO.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
U. Galli, L. Lazzarato, M. Bertinaria, G. Sorba, A. Gasco, S. Parapini, D. Taramelli
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