Mechanical adaptability of a sponge extracellular matrix : evidence for cellular control of mesohyl stiffness in Chondrosia reniformis Nardo
Articolo
Data di Pubblicazione:
2006
Citazione:
Mechanical adaptability of a sponge extracellular matrix : evidence for cellular control of mesohyl stiffness in Chondrosia reniformis Nardo / I.C. Wilkie, L. Parma, F. Bonasoro, G. Bavestrello, C. Cerrano, M.D. Candia Carnevali. - In: JOURNAL OF EXPERIMENTAL BIOLOGY. - ISSN 0022-0949. - 209:22(2006), pp. 4436-4443.
Abstract:
The marine sponge Chondrosia reniformis Nardo consists largely of a collagenous tissue, the mesohyl, which confers a cartilaginous consistency on the whole animal. This investigation was prompted by the incidental observation that, despite a paucity of potentially contractile elements in the mesohyl, intact C. reniformis stiffen noticeably when touched. By measuring the deflection under gravity of beam-shaped tissue samples, it was demonstrated that the flexural stiffness of the mesohyl is altered by treatments that influence cellular activities, including [Ca2+] manipulation, inorganic and organic calcium channel-blockers and cell membrane disrupters, and that it is also sensitive to extracts of C. reniformis tissue that have been repeatedly frozen then thawed. Since the membrane disrupters and tissue extracts cause marked stiffening of mesohyl samples, it is hypothesised that cells in the mesohyl store a stiffening factor and that the physiologically controlled release of this factor is responsible for the touch-induced stiffening of intact animals.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
connective tissue; extracellular matrix; mechanical properties; mutable collagenous tissue; sponge
Elenco autori:
I.C. Wilkie, L. Parma, F. Bonasoro, G. Bavestrello, C. Cerrano, M.D. Candia Carnevali
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