Data di Pubblicazione:
2006
Citazione:
Asymmetric multicomponent copper catalyzed synthesis of chiral propargylamines / F. COLOMBO, M. BENAGLIA, S. ORLANDI, F. USUELLI. - In: JOURNAL OF MOLECULAR CATALYSIS. A: CHEMICAL. - ISSN 1381-1169. - 260:1-2(2006), pp. 128-134.
Abstract:
A three-component stereoselective reaction between an aldehyde, an amine and phenylacetylene to afford optically active propargyl amines in good yields was developed. The reaction is catalysed by copper complexes of enantiomerically pure bis-imines. The best results were obtained with imines readily prepared in very high yields from the commercially available binaphtyl diamine. A very simple experimental procedure at room temperature allowed to obtain optically active propargyl amines in very good yields and enantioselectivity up to 75%. The extremely simple methodology and the mild reaction conditions, as well as the possibility of a modular approach for developing new and more efficient bis-imine-based chiral ligands make the present methodology very attractive.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
multicomponent reactions ; chiral copper(I) complexes ; asymmetric catalysis ; phenylacetylene addition ; chiral propargylamines
Elenco autori:
F. COLOMBO, M. BENAGLIA, S. ORLANDI, F. USUELLI
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