TNF-alpha downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents
Articolo
Data di Pubblicazione:
2006
Citazione:
TNF-alpha downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents / A. Valerio, A. Cardile, V. Cozzi, R. Bracale, L. Tedesco, A. Pisconti, L. Palomba, O. Cantoni, E.G.I. Clementi, S. Moncada, M. Carruba, E. Nisoli. - In: THE JOURNAL OF CLINICAL INVESTIGATION. - ISSN 0021-9738. - 116:10(2006), pp. 2791-2798. [10.1172/JCI28570]
Abstract:
Obesity is assocd. with chronic low-grade inflammation. Thus, at metabolically relevant sites, including adipose tissue and muscle, there is abnormal prodn. of proinflammatory cytokines such as TNF-a. Here we demonstrate that eNOS expression was reduced, with a concomitant redn. of mitochondrial biogenesis and function, in white and brown adipose tissue and in the soleus muscle of 3 different animal models of obesity. The genetic deletion of TNF receptor 1 in obese mice restored eNOS expression and mitochondrial biogenesis in fat and muscle; this was assocd. with less body wt. gain than in obese wild-type controls. Furthermore, TNF-a downregulated eNOS expression and mitochondrial biogenesis in cultured white and brown adipocytes and muscle satellite cells of mice. The NO donors DETA-NO and SNAP prevented the redn. of mitochondrial biogenesis obsd. with TNF-a. Our findings demonstrate that TNF-a impairs mitochondrial biogenesis and function in different tissues of obese rodents by downregulating eNOS expression and suggest a novel pathophysiol. process that sustains obesity. [on SciFinder (R)]
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Body weight ; Mitochondria ; Muscle ; Obesity (TNF-a downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents) ; Tumor necrosis factors Role: BSU (Biological study, unclassified), BIOL (Biological study) (TNF-a downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents) ; Adipose tissue (brown; TNF-a downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents) ; Muscle (satellite cell; TNF-a downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents) ; Tumor necrosis factor receptors Role: BSU (Biological study, unclassified), BIOL (Biological study) (type 1; TNF-a downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents) ; Adipose tissue (white; TNF-a downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents)
Elenco autori:
A. Valerio, A. Cardile, V. Cozzi, R. Bracale, L. Tedesco, A. Pisconti, L. Palomba, O. Cantoni, E.G.I. Clementi, S. Moncada, M. Carruba, E. Nisoli
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