Thin-target excitation functions and optimization of simultaneous production of NCA copper-64 and gallium-66,67 by deuteron induced nuclear reactions on a natural zinc target
Articolo
Data di Pubblicazione:
2003
Citazione:
Thin-target excitation functions and optimization of simultaneous production of NCA copper-64 and gallium-66,67 by deuteron induced nuclear reactions on a natural zinc target / M.L. Bonardi, F. Groppi, C. Birattari, L. Gini, C.H.S. Mainardi, A. Ghioni, E. Menapace, K. Abbas, U. Holzwarth, M.F. Stroosnijder. - In: JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY. - ISSN 0236-5731. - 257:1(2003), pp. 229-241.
Abstract:
Copper-64 is a radionuclide suitable for labeling of a wide range of radiopharmaceuticals for PET imaging, as well as systemic or local radioimmunotherapy of tumors. Among the possible methods for cyclotron production of No Carrier Added (NCA) Cu-64 (Cu-61), we investigated the deuteron irradiation on natural Zn target, via (d,alpha xn) and (d,2pxn) nuclear reactions. This paper reports the preliminary results about the experimental determination and theoretical calculation of thin-target excitation functions in the energy range up to 19 MeV for Cu-61, Cu-64, Ga-66, Ga-67, Zn-65 and Zn-69m. A fast selective radiochemical separation of NCA Cu-64 from Zn target and Ga radionuclides, with quality control tests is described too.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
rame-64; gallio-67; produzione di radioisotopi; ciclotrone; separazioni radiochimiche; controlli di qualità; No Carrier Added; reazioni nucleari; radiofarmaci; PET imaging; modelli nucleari
Elenco autori:
M.L. Bonardi, F. Groppi, C. Birattari, L. Gini, C.H.S. Mainardi, A. Ghioni, E. Menapace, K. Abbas, U. Holzwarth, M.F. Stroosnijder
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