Pathogenetic lung-infiltrating TH1/17 cells as new target in cystic fibrosis lung transplantation recipients : preliminary results
Abstract
Data di Pubblicazione:
2019
Citazione:
Pathogenetic lung-infiltrating TH1/17 cells as new target in cystic fibrosis lung transplantation recipients : preliminary results / M. Paroni, A. Bibi, G. Leccese, R. Macchi, A. Berni, L. Morlacchi, V. Musso, M. Nosotti, P. Landini, A. Palleschi. - In: TRANSPLANT INTERNATIONAL. - ISSN 0934-0874. - 32:suppl. 2(2019), pp. -375. (Intervento presentato al 19. convegno ESOT Congress tenutosi a Copenhagen nel 2019).
Abstract:
lung transplantation is the only treatment for end stage lung cystic fibrosis (CF) disease after maximal therapy. Chronic lung infections in CF patients lead to persistent activation of effector T-cells, in turn causing exacerbated inflammation, tissue damage and. ultimately, lung failure. Recent evidence showed that TH1/17 cells, secreting signature IFN-y and IL-17 proinflammatory cytokines,can worsen inflammatory responses and contribute to CF pathogenesis. However, the pathogenic role of Th1/17 cells in CF-Ltx recipients, has never been characterized.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
M. Paroni, A. Bibi, G. Leccese, R. Macchi, A. Berni, L. Morlacchi, V. Musso, M. Nosotti, P. Landini, A. Palleschi
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