Data di Pubblicazione:
2004
Citazione:
Polymorphism of NCX4016, an NO-releasing derivative of acetylsalicylic acid / A. Foppoli, M.E. Sangalli, A. Maroni, A. Gazzaniga, M.R. Caira, F. Giordano. - In: JOURNAL OF PHARMACEUTICAL SCIENCES. - ISSN 0022-3549. - 93:3(2004), pp. 521-531.
Abstract:
NCX4016 [2-acetoxybenzoic acid 3'-(nitrooxymethyl)phenyl ester] is a recently developed nitrooxy-derivative of aspirin with improved antiinflammatory, analgesic, and antithrombotic activity as well as increased gastrointestinal safety. Systematic polymorphic screening performed with different solvents and preparation methods resulted in the identification of two polymorphs, designated Forms I and II. They were characterized by scanning electron microscopy, powder X-ray diffraction, thermal analyses, and infrared spectroscopy; the crystal structure of polymorph I was solved by single-crystal X-ray analysis and compared with that of aspirin. Finally, intrinsic dissolution rate studies and calculations according to the melting data method were performed to assess the thermodynamic relationship between the two polymorphs.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
polymorphism ; nitrooxyaspirin derivative ; intrinsic dissolution rate ; melting data method ; crystal structure ; thermodynamics
Elenco autori:
A. Foppoli, M.E. Sangalli, A. Maroni, A. Gazzaniga, M.R. Caira, F. Giordano
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