Biological and chemical changes in fluoroquinolone-associated tendinopathies : a systematic review
Articolo
Data di Pubblicazione:
2019
Citazione:
Biological and chemical changes in fluoroquinolone-associated tendinopathies : a systematic review / D.R. Bisaccia, R. Aicale, D. Tarantino, G.M. Peretti, N. Maffulli. - In: BRITISH MEDICAL BULLETIN. - ISSN 0007-1420. - 130:1(2019), pp. 39-49. [10.1093/bmb/ldz006]
Abstract:
INTRODUCTION: The present systematic review investigates the biological and chemical mechanisms that affect the health and structure of tendons following the use of fluoroquinolones (FQs). SOURCES OF DATA: A total of 12 articles were included, organized, and reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. AREAS OF AGREEMENT: Five mechanisms were identified: arrest of proliferation through a decreased activity of cyclin B, CDK-1, CHK-1, and increased PK-1; decrease tenocytes migration through decreased phosphorylation of FAK; decrease type I collagen metabolism through increased MMP-2; chelate effect on ions that influence epigenetics and several enzymes; fluoroquinolones-induced ROS (radical oxygen species) production in mitochondria. AREAS OF CONTROVERSY: There is no definite structure-damage relationship. The dose-effect relationship is unclear. GROWING POINTS: Knowing and defining the damage exerted by FQs plays a role in clinical practice, replacing FQs with other antibacterial drugs or using antioxidants to attenuate their pathological effects. AREAS TIMELY FOR DEVELOPING RESEARCH: Clinical and basic sciences studies for each FQs are necessary.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
achilles; fluoroquinolone; tendinopathy; tendon; tendon rupture
Elenco autori:
D.R. Bisaccia, R. Aicale, D. Tarantino, G.M. Peretti, N. Maffulli
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