Comparison of trabecular bone score and hip structural analysis with FRAX® in postmenopausal women with type 2 diabetes mellitus
Articolo
Data di Pubblicazione:
2017
Citazione:
Comparison of trabecular bone score and hip structural analysis with FRAX® in postmenopausal women with type 2 diabetes mellitus / G. Bonaccorsi, E. Fila, C. Messina, E. Maietti, F.M. Ulivieri, R. Caudarella, P. Greco, G. Guglielmi. - In: AGING CLINICAL AND EXPERIMENTAL RESEARCH. - ISSN 1594-0667. - 29:5(2017 Oct), pp. 951-957. [10.1007/s40520-016-0634-2]
Abstract:
Purpose: To evaluate (a) the performance in predicting the presence of bone fractures of trabecular bone score (TBS) and hip structural analysis (HSA) in type 2 diabetic postmenopausal women compared to a control group and (b) the fracture prediction ability of TBS versus Fracture Risk Calculator (FRAX®) as well as whether TBS can improve the fracture prediction ability of FRAX® in diabetic women. Methods: Eighty diabetic postmenopausal women were matched with 88 controls without major diseases for age and body mass index. The individual 10-year fracture risk was assessed by FRAX® tool for Europe–Italy; bone mineral density (BMD) at lumbar spine, femoral neck and total hip was evaluated through dual-energy X-ray absorptiometry; TBS measurements were taken using the same region of interest as the BMD measurements; HSA was performed at proximal femur with the HSA software. Results: Regarding variables of interest, the only significant difference between diabetic and control groups was observed for the value of TBS (median value: 1.215; IQR 1.138–1.285 in controls vs. 1.173; IQR 1.082–1.217 in diabetic; p = 0.002). The prevalence of fractures in diabetic women was almost tripled than in controls (13.8 vs. 3.4 %; p = 0.02). The receiver operator characteristic curve analysis showed that TBS alone (AUC = 0.71) had no significantly lower discriminative power for fracture prediction in diabetic women than FRAX major adjusted for TBS (AUC = 0.74; p = 0.65). Conclusion: In diabetic postmenopausal women TBS is an excellent tool in identifying fragility fractures.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Fracture risk; FRAX; HSA; Menopause; Osteoporosis; Trabecular bone score; Type 2 diabetes; Absorptiometry, Photon; Aged; Cancellous Bone; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Femur Neck; Hip; Humans; Lumbar Vertebrae; Middle Aged; Osteoporosis, Postmenopausal; Osteoporotic Fractures; Postmenopause; Prevalence; Risk Assessment; Sensitivity and Specificity; Bone Density
Elenco autori:
G. Bonaccorsi, E. Fila, C. Messina, E. Maietti, F.M. Ulivieri, R. Caudarella, P. Greco, G. Guglielmi
Link alla scheda completa: