Cerebrospinal Fluid Level of Aquaporin4: A New Window on Glymphatic System Involvement in Neurodegenerative Disease?
Articolo
Data di Pubblicazione:
2019
Citazione:
Cerebrospinal Fluid Level of Aquaporin4: A New Window on Glymphatic System Involvement in Neurodegenerative Disease? / A. Arighi, A. Di Cristofori, C. Fenoglio, S. Borsa, M. D'Anca, G.G. Fumagalli, M. Locatelli, G. Carrabba, A.M. Pietroboni, L. Ghezzi, T. Carandini, A. Colombi, M. Scarioni, M.A. De Riz, M. Serpente, P.M. Rampini, E. Scarpini, D. Galimberti. - In: JOURNAL OF ALZHEIMER'S DISEASE. - ISSN 1387-2877. - 69:3(2019), pp. 663-669. [10.3233/JAD-190119]
Abstract:
Aquaporin4 (AQP4) is a water channel protein located at astrocyte foot processes that plays a role in glymphatic system, a highly organized fluid transport pathway which seems to be involved in Alzheimer's disease (AD) and normal pressure hydrocephalus (NPH) pathophysiology. Cerebrospinal fluid (CSF) AQP4 levels were determined in 11 patients with AD, 10 patients with NPH, and 9 controls. We found significantly reduced AQP4 in AD patients, a trend in reduction in NPH patients, and a correlation between AQP4 and amyloid-β CSF levels. This study indicates the potential role of AQP4 and glymphatic system in neurodegenerative diseases pathophysiology.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Alzheimer's disease; Aquaporin 4; glymphatic system; normal pressure hydrocephalus
Elenco autori:
A. Arighi, A. Di Cristofori, C. Fenoglio, S. Borsa, M. D'Anca, G.G. Fumagalli, M. Locatelli, G. Carrabba, A.M. Pietroboni, L. Ghezzi, T. Carandini, A. Colombi, M. Scarioni, M.A. De Riz, M. Serpente, P.M. Rampini, E. Scarpini, D. Galimberti
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