A bio-guided assessment of the anti-inflammatory activity of hop extracts (Humulus lupulus L. cv. Cascade) in human gastric epithelial cells
Articolo
Data di Pubblicazione:
2019
Citazione:
A bio-guided assessment of the anti-inflammatory activity of hop extracts (Humulus lupulus L. cv. Cascade) in human gastric epithelial cells / E. Sangiovanni, M. Fumagalli, L. Santagostini, M. Forino, S. Piazza, E. Colombo, O. Taglialatela-Scafati, G. Fico, M. Dell'Agli. - In: JOURNAL OF FUNCTIONAL FOODS. - ISSN 1756-4646. - 57(2019), pp. 95-102.
Abstract:
The present work aims to characterize and investigate the anti-inflammatory activity of hop extracts (cv. Cascade) in an in vitro model of gastric inflammation. The biological activities of hydroalcoholic and aqueous extracts from cones were evaluated by comparing IL-8 inhibition induced by TNFα. The hydroalcoholic extract demonstrated a higher inhibitory effect, which was just slightly affected by an in vitro simulated gastric digestion. The identification of active compounds was performed by a bio-guided fractionation which afforded 11 fractions, one of which inhibited IL-8 release in a concentration-dependent fashion in human gastric epithelial AGS cells. Phytochemical analysis revealed xanthohumol A and xanthohumol D as the main active components. The present study provides some experimental evidences that Humulus lupulus L. may exert an anti-inflammatory activity on the gastric district by the inhibition of the IL-8 secretion, partially due to its prenylated chalcones content.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
AGS cells; Gastric inflammation; Hop; Humulus lupulus L.; IL-8; Xanthohumol; Food Science; Medicine (miscellaneous); Nutrition and Dietetics
Elenco autori:
E. Sangiovanni, M. Fumagalli, L. Santagostini, M. Forino, S. Piazza, E. Colombo, O. Taglialatela-Scafati, G. Fico, M. Dell'Agli
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