Increased incidence of colon cancer among individuals younger than 50 years : a 17 years analysis from the cancer registry of the municipality of Milan, Italy
Articolo
Data di Pubblicazione:
2019
Citazione:
Increased incidence of colon cancer among individuals younger than 50 years : a 17 years analysis from the cancer registry of the municipality of Milan, Italy / A.G. Russo, A. Andreano, A. Sartore-Bianchi, G. Mauri, A. Decarli, S. Siena. - In: CANCER EPIDEMIOLOGY. - ISSN 1877-7821. - 60(2019), pp. 134-140. [10.1016/j.canep.2019.03.015]
Abstract:
Background: Colorectal cancer (CRC) overall incidence has been decreasing in the last decade. However, there is
evidence of an increasing frequency of early-onset CRC in young individuals in several countries. The aim of this
study is to evaluate the trends of CRC occurrence over 17 years in the municipality of Milan, Italy, focusing on
early-onset CRC.
Population and methods: This retrospective study was performed using the Cancer Registry of the municipality of
Milan, including all cases of CRC diagnosed 1999-2015. Incidence rates were stratified by age and anatomic
subsite, and trends over time were measured using the estimated annual percentage change. Age-period-cohort
modelling was used to disentangle the different effects.
Results: 18,783 cases of CRC were included. CRC incidence rates among individuals aged 50–60 years declined
annually by 3% both in colon and in rectal cancer. Conversely, in adults younger than 50 years, overall CRC
occurrence increased annually by 0.7%, with a diverging trend for colon (+2.6%) and rectal (−5.3%) cancer.
Among individuals aged 60 years and older, CRC incidence rates increased by 1.0% annually up to 2007, and
decrease thereafter by 4% per year, both for colon and rectal cancer. Age-period-cohort models showed a reduction
of CRC risk for the cohorts born up to 1979, followed by an increase in younger cohorts. In contrast,
rectal cancer among women showed a systematic risk decrease for all birth cohorts.
Conclusions: The study highlights increasing incidence of colon cancer in younger subjects and a decrease in
incidence rates for rectal cancer in females.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Age-period-cohort; Colorectal cancer; Incidence; Young age
Elenco autori:
A.G. Russo, A. Andreano, A. Sartore-Bianchi, G. Mauri, A. Decarli, S. Siena
Link alla scheda completa: