Calcineurin primes immature gonadotropin-releasing hormone-secreting neuroendocrine cells for migration
Articolo
Data di Pubblicazione:
2008
Citazione:
Calcineurin primes immature gonadotropin-releasing hormone-secreting neuroendocrine cells for migration / R. Zaninetti, S. Tacchi, J. Erriquez, C. Distasi, R. Maggi, A. Cariboni, F. Condorelli, P.L. Canonico, A.A. Genazzani. - In: MOLECULAR ENDOCRINOLOGY. - ISSN 0888-8809. - 22:3(2008), pp. 729-736. [10.1210/me.2007-0277]
Abstract:
During development, many neurons display calcium- dependent migration, but the role of this messenger in regulating gene expression leading to this event has not yet been elucidated. Among the decoders of calcium signals is calcineurin, a Ca2 / calmodulin serine/threonine phosphatase that has been involved in both short-term and long-term cellular changes. By using immortalized GnRH-secreting neurons, we now show that, in vitro, Ca2 - dependent gene expression, proceeding via calcineurin and the transcription factor nuclear factor of activated T cells, is a key player controlling the chemomigratory potential of developing GnRH-secreting neurons. Furthermore, our data highlight the switch nature of this phosphatase, whose activation or inactivation guides cells to proceed from one genetic program to the next
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
neuron ; calcium ; migration ; GnRH
Elenco autori:
R. Zaninetti, S. Tacchi, J. Erriquez, C. Distasi, R. Maggi, A. Cariboni, F. Condorelli, P.L. Canonico, A.A. Genazzani
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