PD-L1 expression in tumour microenvironment supports the rationale for immune checkpoint blockade in classic Kaposi's sarcoma
Articolo
Data di Pubblicazione:
2019
Citazione:
PD-L1 expression in tumour microenvironment supports the rationale for immune checkpoint blockade in classic Kaposi's sarcoma / G. Genovese, L. Venegoni, D. Fanoni, A. Tourlaki, L. Brambilla, E. Berti. - In: JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY. - ISSN 0926-9959. - (2019). [Epub ahead of print] [10.1111/jdv.15543]
Abstract:
Kaposi's sarcoma (KS), a rare human herpesvirus type 8 (HHV8)-associated lymphangioproliferative disorder, is usually skin-limited and slowly progressing.1 However, in the rare cases of locally aggressive or visceral KS refractory to chemotherapy, programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) blockers, a class of immune-checkpoint inhibitors which acts via the circumvention of tumour immune escape and has shown durable anti-tumour effects in specific subsets of patients with different solid tumours, have been invoked as a promising therapy.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Kaposi's sarcoma; immune checkpoint blockade; immunohistochemistry; programmed cell death-1; programmed cell death-ligand 1; tumour microenvironment
Elenco autori:
G. Genovese, L. Venegoni, D. Fanoni, A. Tourlaki, L. Brambilla, E. Berti
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