Data di Pubblicazione:
2008
Citazione:
Neuroactive steroids : state of the art and new perspectives / C. Melcangi, L.M. Garcia-Segura, A.G. Mensah-Nyagan. - In: CELLULAR AND MOLECULAR LIFE SCIENCES. - ISSN 1420-682X. - 65:5(2008), pp. 777-797.
Abstract:
Neuroactive steroids include synthetic steroidal
compounds and endogenous steroids, produced
by endocrine glands (hormonal steroids) or the
nervous tissue (neurosteroids), which regulate neural
functions. These steroids bind to nuclear receptors or
act through the activation of membrane-associated
signaling pathways to modulate various important
processes including the development of the nervous system, neural plasticity and the adaptive responses of
neurons and glial cells under pathological conditions.
Reviewed and updated in the present paper are the
pleiotropic and protective abilities of neuroactive
steroids. The fundamental evidence and knowledge
gained constitute a profound background that offers
interesting possibilities for developing effective strategies
against several disorders of the nervous system.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Brain; Glia; Mitochondria; Myelin; Neuroprotection; Neurosteroids; Spinal cord; Steroidogenesis
Elenco autori:
C. Melcangi, L.M. Garcia-Segura, A.G. Mensah-Nyagan
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