Data di Pubblicazione:
2007
Citazione:
ASYMMETRIC (ADMA) AND SYMMETRIC (SDMA) DIMETHYLARGININE
IN SEPTIC PATIENTS / M. Albicini, R. Paroni, R. Pavlovic, M. Umbrello, A. Galimberti, F. Sacconi, G. Iapichino. - In: CLINICAL NUTRITION SUPPLEMENTS. - ISSN 1744-1161. - 2:2(2007), pp. 89-89. ((Intervento presentato al 29. convegno 29th Congress of ESPEN tenutosi a Prague, Czech Republic nel 2007.
Abstract:
Rationale: Endothelium-derived NO plays a critical rule in
regulation of blood pressure, preservation of organ perfusion
and interaction between vascular endothelium and
blood platelets/leukocytes. ADMA is an endogenous nonselective
inhibitor of nitric oxide (NO) synthase and SDMA
competes with arginine for cellular transport. The aim of
the study was to investigate if ADMA and SDMA are increased
in ‘‘sepsis syndrome’’ due to protein catabolism and
eventually to decreased epato-renal elimination.
Methods: Twenty-nine consecutive septic patients, as
defined by the ACCP/SCCM1 were enrolled. Blood sampling
was performed on admission day (T0), 3rd(T3), 6th(T6),
9th(T9), 12th(T12). ADMA and SDMA (mmol/L)were measured
by HPLC. ADMA and SDMA were also measured in 77 healthy
volunteers. SAPSII at ICU admission, SOFA score, and sepsis
status1 were recorded daily. Data are presented as
mean7SD. Differences between groups were analysed with
Student’s t-test, ANOVA and Scheffe` test. Significance was
set at po0.05.
Results: Mean ADMA (1.0470.44 vs 0.4670.13, n ¼ 116,
po0.0000) and SDMA levels (2.271.3 vs 0.470.09, n ¼ 116,
po0.0000), all samples together, are higher than in healthy
volunteers. SDMA level during Severe Sepsis/Septic
Shock(1)days is significantly higher than during Sirs/Sepsis
days (2.471.35 vs 1.8871.22, n ¼ 116, p ¼ 0.038) while
ADMA (1.170.51 vs 0.9570.29, n ¼ 116, p ¼ 0.07) shows a
trend. Patients who developed Septic Shock along ICU stay
have higher values of ADMA (1.1370.5, n ¼ 64 vs 0.937
0.32, n ¼ 52, po0.013) and SDMA (2.6271.48, n ¼ 64 vs
1.6970.86, n ¼ 52, p ¼ 0.0001).
Conclusions: ADMA and SDMA levels are consistently higher
in critically ill septic patients than in healthy volunteers.
These values are even higher in Severe Sepsis/Septic Shock
status.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
M. Albicini, R. Paroni, R. Pavlovic, M. Umbrello, A. Galimberti, F. Sacconi, G. Iapichino
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