Data di Pubblicazione:
2016
Citazione:
In silico prediction and characterization of protein post-translational modifications / E. Gianazza, C. Parravicini, R. Primi, I. Miller, I. Eberini. - In: JOURNAL OF PROTEOMICS. - ISSN 1874-3919. - 134(2016 Feb 16), pp. 65-75.
Abstract:
This review outlines the computational approaches and procedures for predicting post translational modification (PTM)-induced changes in protein conformation and their influence on protein function(s), the latter being assessed as differential affinity in interaction with either low (ligands for receptors or transporters, substrates for enzymes) or high molecular mass molecules (proteins or nucleic acids in supramolecular assemblies). The scope for an in silico approach is discussed against a summary of the in vitro evidence on the structural and functional outcome of protein PTM.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Homology modeling; Molecular docking; Molecular dynamics; Molecular modeling; PTM prediction; Supramolecular assembly; Computer Simulation; Protein Processing, Post-Translational; Proteins; Sequence Analysis, Protein; Molecular Docking Simulation
Elenco autori:
E. Gianazza, C. Parravicini, R. Primi, I. Miller, I. Eberini
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