Lupin LILPKHSDAD (P5) peptide is a novel bi-functional inhibitor of PCSK9, a new target for the hypercholesterolemia treatment
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Data di Pubblicazione:
2018
Citazione:
Lupin LILPKHSDAD (P5) peptide is a novel bi-functional inhibitor of PCSK9, a new target for the hypercholesterolemia treatment / C. Lammi, G. Grazioso, C. Bollati, G. Aiello, G. Vistoli, A. Arnoldi. ((Intervento presentato al 16. convegno Workshop on Bioactive Peptides tenutosi a Napoli nel 2018.
Abstract:
Proprotein convertase subtilisin/kexin type 9 (PCSK9) has been recently identified as a new target for hypercholesterolemia treatment.[1] Interestingly, we have observed that in mild hypercholesterolemic subjects, which had consumed lupin protein (30 g/day) for 4 weeks, the final circulating PCSK9 level had been reduced by 8.5% versus baseline value. In addition, we have also provided evidences related to the mechanism of action by which lupin peptides may modulate PCSK9 in HepG2 cells.[2] In this context, we have demonstrated that LILPKHSDAD (P5), a peptide deriving from peptic lupin protein hydrolysis and absorbable at intestinal level, is able to modulate the PCSK9 target with a dual mechanism of action. In particular, P5 peptide reduces PCSK9 production and secretion through a decrease of HNF1-alpha in HepG2 cells and an absorbed lupin peptide is able to inhibit the protein-protein interaction between PCSK9 and the LDL receptor with an IC50 value equal to 1.6±0.33 μM. All these evidences contribute to explain the beneficial hypocholesterolemic effects of lupin peptide, which were observed in clinical studies and opening a new area of investigation on plant proteins.
Tipologia IRIS:
14 - Intervento a convegno non pubblicato
Elenco autori:
C. Lammi, G. Grazioso, C. Bollati, G. Aiello, G. Vistoli, A. Arnoldi
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