Nonpeptide Integrin Antagonists : RGD Mimetics Incorporating Substituted Azabicycloalkanes as Amino Acid Replacements
Articolo
Data di Pubblicazione:
2007
Citazione:
Nonpeptide Integrin Antagonists : RGD Mimetics Incorporating Substituted Azabicycloalkanes as Amino Acid Replacements / L. Manzoni, M. Bassanini, L. Belvisi, I. Motto, C. Scolastico, M. Castorina, C. Pisano. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - :8(2007), pp. 1309-1317. [10.1002/ejoc.200600840]
Abstract:
Azabicyclo[4.3.0]alkanes appropriately substituted on both cycles have been synthesized as potential scaffold mimics of
the RGD signaling motif of integrin. Two sets of functionalized azabicycloalkanes have been examined. In vitro assays established that 21 has a good affinity specifically for αvβ3.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Angiogenesis; Antitumor agent; Azabicycloalkanes; Lactams; RGD mimetics
Elenco autori:
L. Manzoni, M. Bassanini, L. Belvisi, I. Motto, C. Scolastico, M. Castorina, C. Pisano
Link alla scheda completa: