Data di Pubblicazione:
2019
Citazione:
Phytochemical analyses and pharmacological screening of Neem oil / S. Cesa, F. Sisto, G. Zengin, D. Scaccabarozzi, A.K. Kokolakis, M.M. Scaltrito, R. Grande, M. Locatelli, F. Cacciagrano, L. Angiolella, C. Campestre, A. Granese, P. Chimenti, N. Basilico. - In: SOUTH AFRICAN JOURNAL OF BOTANY. - ISSN 0254-6299. - 120(2019 Jan), pp. 331-337.
Abstract:
An Italian certified Neemseed oil was characterized through the color analysis, the HPLC phenolic fingerprint and
the preliminary evaluation of the cytotoxicity profile against the human macrophage (THP-1) cell line. Moreover,
a wide screening of its enzyme inhibitory profile, antimicrobial activity towards Helicobacter pylori, several
Candida spp. and Malassezia furfur strains and antiprotozoal activity against Plasmodium falciparum, Leishmania
infantum and Leishmania tropica were performed. Neem seed oil demonstrated lowtoxicity and a great inhibitory
efficacy against tyrosinase and lipase enzymes. Antimalarial and anti-leishmanial activities were also demonstrated,
but weak or no activity was evidenced against Helicobacter pylori, Candida and Malassezia strains. Overall,
these findings encourage the potential use of this natural product in some disease treatments and justify its use in
traditional medicine.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Color analysis; HPLC-PDA; H. pylori; Neem oil; Malaria; Leishmania; Enzyme inhibition
Elenco autori:
S. Cesa, F. Sisto, G. Zengin, D. Scaccabarozzi, A.K. Kokolakis, M.M. Scaltrito, R. Grande, M. Locatelli, F. Cacciagrano, L. Angiolella, C. Campestre, A. Granese, P. Chimenti, N. Basilico
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