One step access to oxindole-based β-lactams through Ugi four-center three-component reaction
Articolo
Data di Pubblicazione:
2018
Citazione:
One step access to oxindole-based β-lactams through Ugi four-center three-component reaction / G. Rainoldi, G. Lesma, C. Picozzi, L. Lo Presti, A. Silvani. - In: RSC ADVANCES. - ISSN 2046-2069. - 8:61(2018 Oct 24), pp. 34903-34910. [10.1039/c8ra08165d]
Abstract:
A multicomponent Ugi reaction involving isatin, isocyanide and β-amino acid components has been developed. The reactions proceeded smoothly to give β-lactam-containing 3,3-disubstituted oxindoles in only one step and generally high yields. When chiral, non racemic, β-amino acids were used, products were obtained as enantiomerically pure β-lactams diastereoisomers, whose relative stereochemistry was determined by X-ray analysis. For one compound, a weak antibacterial activity has been preliminarily highlighted.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Chemistry (all); Chemical Engineering (all)
Elenco autori:
G. Rainoldi, G. Lesma, C. Picozzi, L. Lo Presti, A. Silvani
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