Surgery for advanced colorectal cancer in elderly patients with special emphasis for radio-chemotherapy role
Articolo
Data di Pubblicazione:
2007
Citazione:
Surgery for advanced colorectal cancer in elderly patients with special emphasis for radio-chemotherapy role / A. Chiappa, E. Bertani, A.P. Zbar, R. Biffi, F. Biella, M. Bellomi, G. Zampino, N. Fazio, D. Poldi, U. Page, B. Andreoni. - In: HEPATO-GASTROENTEROLOGY. - ISSN 0172-6390. - 54:75(2007 Apr), pp. 740-745.
Abstract:
BACKGROUND/AIMS: To compare the short- and long-term outcome of older and younger patients with advanced colorectal cancer who underwent elective surgery. METHODOLOGY: Six hundred and ninety-two patients were analyzed. Four hundred and seventy-nine patients were < 70 years (group 1), and 213 were > or = 70 years (group 2). RESULTS: The overall peroperative mortality rate in younger patients was 0.8% (n = 7), and 1.4% (n = 3) in the elderly (p = NS); morbidity was 35% and 42%, respectively (p = NS). On univariate analysis, elderly patients had a worse overall survival (OS) compared to younger, when only patients undergoing postoperative chemo-radiotherapy were considered (54% OS vs. 67% OS at 5 years; p = 0.03). Using logistic regression analysis, tumor stage (p < 0.0001) and radicality of surgery (p < 0.0001), were strongly associated with OS rates in the elderly. CONCLUSIONS: Colorectal surgery for malignancy can be performed safely in the elderly. Clinical trials are necessary to understand the real advantage of adjuvant or palliative treatments in these patients
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Chemotherapy; Elderly; Postoperative mortality; Radiotherapy; Risk factors; Survival
Elenco autori:
A. Chiappa, E. Bertani, A.P. Zbar, R. Biffi, F. Biella, M. Bellomi, G. Zampino, N. Fazio, D. Poldi, U. Page, B. Andreoni
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