Size control in mammalian cells involves modulation of both growth rate and cell cycle duration
Articolo
Data di Pubblicazione:
2018
Citazione:
Size control in mammalian cells involves modulation of both growth rate and cell cycle duration / C. Cadart, S. Monnier, J. Grilli, R. Attia, E. Terriac, B. Baum, M. COSENTINO LAGOMARSINO, M. Piel. - In: NATURE COMMUNICATIONS. - ISSN 2041-1723. - 9:1(2018 Aug 16). [10.1038/s41467-018-05393-0]
Abstract:
Despite decades of research, how mammalian cell size is controlled remains unclear because of the difficulty of directly measuring growth at the single-cell level. Here we report direct measurements of single-cell volumes over entire cell cycles on various mammalian cell lines and primary human cells. We find that, in a majority of cell types, the volume added across the cell cycle shows little or no correlation to cell birth size, a homeostatic behavior called “adder”. This behavior involves modulation of G1 or S-G2 duration and modulation of growth rate. The precise combination of these mechanisms depends on the cell type and the growth condition. We have developed a mathematical framework to compare size homeostasis in datasets ranging from bacteria to mammalian cells. This reveals that a near-adder behavior is the most common type of size control and highlights the importance of growth rate modulation to size control in mammalian cells.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Chemistry (all); Biochemistry, Genetics and Molecular Biology (all); Physics and Astronomy (all)
Elenco autori:
C. Cadart, S. Monnier, J. Grilli, R. Attia, E. Terriac, B. Baum, M. COSENTINO LAGOMARSINO, M. Piel
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