Intestinal health benefits of bovine whey proteins after simulated gastrointestinal digestion
Articolo
Data di Pubblicazione:
2018
Citazione:
Intestinal health benefits of bovine whey proteins after simulated gastrointestinal digestion / A.R. Corrochano, E. Arranz, I. De Noni, M. Stuknytė, A. Ferraretto, P.M. Kelly, V. Buckin, L. Giblin. - In: JOURNAL OF FUNCTIONAL FOODS. - ISSN 1756-4646. - 49(2018 Oct), pp. 526-535. [10.1016/j.jff.2018.08.043]
Abstract:
Bovine whey proteins are widely incorporated in foods for their nutritional, health promoting and functional
value. However, whey proteins are readily digested in the upper gut. The objective of this study was to determine
the fate and bioactivity of bovine whey proteins post simulated gastrointestinal digestion (GID). Our results
demonstrated that β-lactoglobulin and α-lactalbumin post GID protect human intestinal cells from free radical
formation. Post GID, lactoferrin significantly increased the amount of the intracellular antioxidant enzymes
superoxide dismutase 1, 2 and thioredoxin. In addition, all whey samples post GID inhibited the activity of the
dipeptidyl peptidase IV. However, the conditions of the gut destroyed the ability of whey proteins to act as
glucagon-like peptide-1 secretagogues. The peptide profiles of GID whey protein isolate, β-lactoglobulin, α-
lactalbumin, bovine serum albumin and lactoferrin revealed several peptides with bioactive potential.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Whey protein; In vitro digestion; Bioactive peptide; Glucagon-like peptide-1; Dipeptidyl peptidase IV inhibitor; Antioxidant activity
Elenco autori:
A.R. Corrochano, E. Arranz, I. De Noni, M. Stuknytė, A. Ferraretto, P.M. Kelly, V. Buckin, L. Giblin
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