The spectrum of canine cutaneous perivascular wall tumors : morphologic, phenotypic and clinical characterization
Articolo
Data di Pubblicazione:
2007
Citazione:
The spectrum of canine cutaneous perivascular wall tumors : morphologic, phenotypic and clinical characterization / G. Avallone, P. Helmbold, M. Caniatti, D. Stefanello, R.C. Nayak, P. Roccabianca. - In: VETERINARY PATHOLOGY. - ISSN 0300-9858. - 44:5(2007), pp. 607-620. [10.1354/vp.44-5-607]
Abstract:
Perivascular wall tumors (PWTs) are defined as neoplasms deriving from mural
cells of blood vessels, excluding the endothelial lining. The spectrum of human
cutaneous PWT includes glomus tumor, hemangiopericytoma (HEP), myopericytoma,
angioleiomyoma/sarcoma, angiomyofibroblastoma, and angiofibroma. The purpose of
this study was to revise clinical presentation, cytology, histopathology, and
immunohistology of canine cutaneous PWT with cytology typical of canine HEP.
Diagnosis was established on the basis of vascular growth patterns (staghorn,
placentoid, perivascular whorling, bundles from media) and immunohistology,
including 7 smooth muscle markers and the cell membrane ganglioside of unknown
origin recognized by the antibody 3G5 (CMG-3G5). Twenty cases were included. Ages
ranged from 6 to 13 years; 12 dogs were males and 8 were females, and there was a
prevalence of crossbreeds. Tumors arose from a single site with preferential
acral location (10/20). Cytology revealed moderate to high cellularity in all
cases, cohesive groups of cells (19/20), capillaries (18/20), and bi- to
multinucleated cells (18/20). Six myopericytomas, 5 angioleiomyomas, 2
angioleiomyosarcomas, 2 HEP, 1 angiofibroma, and 1 adventitial tumor were
identified. A definitive diagnosis was not possible in 3 cases. Smoothelin, heavy
caldesmon, desmin, myosin, calponin, and CMG-3G5 were the most valuable markers
to differentially diagnose canine PWT. Similar to reports in humans, canine HEP
embodied a spectrum of neoplastic entities arising from different vascular mural
cells. Before canine PWTs are assimilated into one prognostic category, a
consistent classification and characterization of their biology is necessary. As
proposed in humans, HEP should also be considered a diagnosis of exclusion in
dogs
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
3G5; Dogs; Hemangiopericytoma; Immunohistochemistry; Myopericytoma; Vascular wall; Whorling
Elenco autori:
G. Avallone, P. Helmbold, M. Caniatti, D. Stefanello, R.C. Nayak, P. Roccabianca
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