Micro- and nanoscale modification of poly(2-hydroxyethyl methacrylate) hydrogels by AFM lithography and nanoparticle incorporation
Articolo
Data di Pubblicazione:
2005
Citazione:
Micro- and nanoscale modification of poly(2-hydroxyethyl methacrylate) hydrogels by AFM lithography and nanoparticle incorporation / A. Podestà, E. Ranucci, L. Macchi, G. Bongiorno, P. Ferruti, P. Milani. - In: JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY. - ISSN 1533-4880. - 5:3(2005), pp. 429-436. [10.1166/jnn.2005.061]
Abstract:
Poly(2-hydroxyethyl methacrylate) (PHEMA) hydrogels are widely used as biomaterials. Due to their unique combination of biocompatibility and good mechanical properties, they have potential as scaffolds for tissue engineering applications. To this purpose, topographic and chemical patterning at the nano- to the mesoscale is crucial in order to favor and to characterize cell adhesion and proliferation. Here we report the characterization of as-prepared and patterned PHEMA hydrogels, produced by conventional radical polymerization in water and dimethylformamide. We have obtained chemical and morphological micro- and nanoscale patterning by atomic force microscopy based lithography. We also demonstrate that it is possible to incorporate carbon nanoparticles in the hydrogel matrix by supersonic cluster beam deposition.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Experimental atomic force microscopy ; biomedical materials ; carbon ; nanolithography ; nanoparticles ; nanopatterning ; polymer gels ; polymerisation ; tissue engineering ; AFM lithography ; nanoparticle incorporation ; poly(2-hydroxyethyl methacrylate) (PHEMA) hydrogels ; biomaterials ; biocompatibility ; mechanical properties ; scaffolds ; tissue engineering ; topographic patterning ; cell adhesion ; proliferation ; water ; conventional radical polymerization ; dimethylformamide ; chemical nanoscale patterning ; morphological nanoscale patterning ; nanoscale patterning ; atomic force microscopy based lithography ; carbon nanoparticles ; supersonic cluster beam deposition ; C/ A8116R Nanopatterning A8116N Nanolithography A8270G Gels and sols A6125H Structure of macromolecular and polymer solutions (solubility, swelling, etc.) ; polymer melts A8235 Polymer reactions and polymerization A8770M Biomedical materials A8725 Cellular biophysics/ C/el
Elenco autori:
A. Podestà, E. Ranucci, L. Macchi, G. Bongiorno, P. Ferruti, P. Milani
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