Data di Pubblicazione:
2018
Citazione:
From jamming to collective cell migration through a boundary induced transition / O. Chepizhko, M.C. Lionetti, C. Malinverno, C. Giampietro, G. Scita, S. Zapperi, C.A.M. La Porta. - In: SOFT MATTER. - ISSN 1744-683X. - 14:19(2018 May 01), pp. 3774-3782. [10.1039/c8sm00128f]
Abstract:
Cell monolayers provide an interesting example of active matter, exhibiting a phase transition from flowing to jammed states as they age. Here we report experiments and numerical simulations illustrating how a jammed cellular layer rapidly reverts to a flowing state after a wound. Quantitative comparison between experiments and simulations shows that cells change their self-propulsion and alignment strength so that the system crosses a phase transition line, which we characterize by finite-size scaling in an active particle model. This wound-induced unjamming transition is found to occur generically in epithelial, endothelial and cancer cells.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
O. Chepizhko, M.C. Lionetti, C. Malinverno, C. Giampietro, G. Scita, S. Zapperi, C.A.M. La Porta
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