Data di Pubblicazione:
1982
Citazione:
Colostral t lymphocytes detected by intracytoplasmic and membrane markers / C. Pignata, L. Nespol, R. Maccario, S. Siena, G. M Ingrat, M. Mazzucco, A.G. Ugazio. - In: BIOLOGY OF THE NEONATE. - ISSN 0006-3126. - 42:5-6(1982), pp. 217-221. [10.1159/000241602]
Abstract:
Colostral lymphocytes were studied using two established T-cell markers: Intracytoplasmic alpha-naphtyl-acetate esterase (ANAE) staining and membrane receptors for sheep erythrocytes (E rosettes). ANAE staining allowed counting and identification of T-cell subsets independently of the status of membrane structures and receptors frequently altered in colostral cells. The fact that a sizeable number of colostral lymphocytes had the same phenotype as the majority of mature circulating peripheral blood lymphocytes supports the hypothesis that colostral lymphocytes may play a role in protecting neonates against infections, in transferring immune information to the newborn, or in modulating the immune response via release of soluble factors. A considerable percentage of colostral T lymphocytes are ANAE-negative. This phenotype is similar to that observed among thymocytes.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Colostrum; Neonatal immunology; Newborn; T lymphocytes; Cell Separation; Centrifugation, Density Gradient; Colostrum; Cytoplasm; Female; Humans; Receptors, Antigen, T-Cell; Rosette Formation; T-Lymphocytes; Carboxylic Ester Hydrolases; Naphthol AS D Esterase; Pediatrics, Perinatology and Child Health; Developmental Biology
Elenco autori:
C. Pignata, L. Nespol, R. Maccario, S. Siena, G. M Ingrat, M. Mazzucco, A.G. Ugazio
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