Short Physical Performance Battery and all-cause mortality : systematic review and meta-analysis
Articolo
Data di Pubblicazione:
2016
Citazione:
Short Physical Performance Battery and all-cause mortality : systematic review and meta-analysis / R. Pavasini, J. Guralnik, J.C. Brown, M. di Bari, M. Cesari, F. Landi, B. Vaes, D. Legrand, J. Verghese, C. Wang, S. Stenholm, L. Ferrucci, J.C. Lai, A.A. Bartes, J. Espaulella, M. Ferrer, J.Y. Lim, K.E. Ensrud, P. Cawthon, A. Turusheva, E. Frolova, Y. Rolland, V. Lauwers, A. Corsonello, D.G. Kirk, R. Ferrari, S. Volpato, G. Campo. - In: BMC MEDICINE. - ISSN 1741-7015. - 14:1(2016), pp. 215.1-215.9. [10.1186/s12916-016-0763-7]
Abstract:
BACKGROUND:
The Short Physical Performance Battery (SPPB) is a well-established tool to assess lower extremity physical performance status. Its predictive ability for all-cause mortality has been sparsely reported, but with conflicting results in different subsets of participants. The aim of this study was to perform a meta-analysis investigating the relationship between SPPB score and all-cause mortality.
METHODS:
Articles were searched in MEDLINE, the Cochrane Library, Google Scholar, and BioMed Central between July and September 2015 and updated in January 2016. Inclusion criteria were observational studies; >50 participants; stratification of population according to SPPB value; data on all-cause mortality; English language publications. Twenty-four articles were selected from available evidence. Data of interest (i.e., clinical characteristics, information after stratification of the sample into four SPPB groups [0-3, 4-6, 7-9, 10-12]) were retrieved from the articles and/or obtained by the study authors. The odds ratio (OR) and/or hazard ratio (HR) was obtained for all-cause mortality according to SPPB category (with SPPB scores 10-12 considered as reference) with adjustment for age, sex, and body mass index.
RESULTS:
Standardized data were obtained for 17 studies (n = 16,534, mean age 76 ± 3 years). As compared to SPPB scores 10-12, values of 0-3 (OR 3.25, 95%CI 2.86-3.79), 4-6 (OR 2.14, 95%CI 1.92-2.39), and 7-9 (OR 1.50, 95%CI 1.32-1.71) were each associated with an increased risk of all-cause mortality. The association between poor performance on SPPB and all-cause mortality remained highly consistent independent of follow-up length, subsets of participants, geographic area, and age of the population. Random effects meta-regression showed that OR for all-cause mortality with SPPB values 7-9 was higher in the younger population, diabetics, and men.
CONCLUSIONS:
An SPPB score lower than 10 is predictive of all-cause mortality. The systematic implementation of the SPPB in clinical practice settings may provide useful prognostic information about the risk of all-cause mortality. Moreover, the SPPB could be used as a surrogate endpoint of all-cause mortality in trials needing to quantify benefit and health improvements of specific treatments or rehabilitation programs. The study protocol was published on PROSPERO (CRD42015024916).
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
All-cause mortality; Meta-analysis; Physical function; Short Physical Performance Battery; Aged; Female; Geriatric Assessment; Humans; Lower Extremity; Male; Odds Ratio; Prognosis; Risk Assessment; Exercise Test; Mortality; Medicine (all)
Elenco autori:
R. Pavasini, J. Guralnik, J.C. Brown, M. di Bari, M. Cesari, F. Landi, B. Vaes, D. Legrand, J. Verghese, C. Wang, S. Stenholm, L. Ferrucci, J.C. Lai, A.A. Bartes, J. Espaulella, M. Ferrer, J.Y. Lim, K.E. Ensrud, P. Cawthon, A. Turusheva, E. Frolova, Y. Rolland, V. Lauwers, A. Corsonello, D.G. Kirk, R. Ferrari, S. Volpato, G. Campo
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