Designing pharmaceutical trials for sarcopenia in frail older adults : EU/US task force recommendations
Articolo
Data di Pubblicazione:
2013
Citazione:
Designing pharmaceutical trials for sarcopenia in frail older adults : EU/US task force recommendations / B. Vellas, M. Pahor, T. Manini, D. Rooks, J.M. Guralnik, J. Morley, S. Studenski, W. Evans, C. Asbrand, R. Fariello, S. Pereira, Y. Rolland, G. Abellan Van Kan, M. Cesari, W.M.C. Chumlea, R. Fielding. - In: THE JOURNAL OF NUTRITION, HEALTH & AGING. - ISSN 1279-7707. - 17:7(2013), pp. 612-618.
Abstract:
An international task force of academic and industry leaders in sarcopenia research met on December 5, 2012 in Orlando, Florida to develop guidelines for designing and executing randomized clinical trials of sarcopenia treatments. The Task Force reviewed results from previous trials in related disease areas to extract lessons relevant to future sarcopenia trials, including practical issues regarding the design and conduct of trials in elderly populations, the definition of appropriate target populations, and the selection of screening tools, outcome measures, and biomarkers. They discussed regulatory issues, the challenges posed by trials of different types of interventions, and the need for standardization and harmonization. The Task Force concluded with recommendations for advancing the field toward better clinical trials.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
clinical trial; frailty; intervention; Sarcopenia; skeletal muscle; Advisory Committees; Aged; Aged, 80 and over; Congresses as Topic; European Union; Humans; Sarcopenia; United States; Frail Elderly; Randomized Controlled Trials as Topic; Research Design; Medicine (miscellaneous); Nutrition and Dietetics; Geriatrics and Gerontology
Elenco autori:
B. Vellas, M. Pahor, T. Manini, D. Rooks, J.M. Guralnik, J. Morley, S. Studenski, W. Evans, C. Asbrand, R. Fariello, S. Pereira, Y. Rolland, G. Abellan Van Kan, M. Cesari, W.M.C. Chumlea, R. Fielding
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