Impact of inflammation on the relationship among alcohol consumption, mortality, and cardiac events : the health, aging, and body composition study
Articolo
Data di Pubblicazione:
2006
Citazione:
Impact of inflammation on the relationship among alcohol consumption, mortality, and cardiac events : the health, aging, and body composition study / C. Maraldi, S. Volpato, S.B. Kritchevsky, M. Cesari, E. Andresen, C. Leeuwenburgh, T.B. Harris, A.B. Newman, A. Kanaya, K.C. Johnson, N. Rodondi, M. Pahor. - In: ARCHIVES OF INTERNAL MEDICINE. - ISSN 0003-9926. - 166:14(2006), pp. 1490-1497.
Abstract:
Background: Uncertainty remains about the overall survival benefit of alcohol consumption and the mechanisms underlying the cardioprotective effect of light to moderate alcohol intake. Recent evidence suggests an anti-inflammatory effect of light to moderate alcohol consumption. We investigated the relationship of alcohol intake with all-cause mortality and cardiac events and evaluated whether this relationship is mediated or modified by inflammatory markers. Methods: The analysis included 2487 subjects, aged 70 to 79 years, without baseline coronary heart disease (CHD) or heart failure (HF), participating in the Health, Aging, and Body Composition study. All-cause mortality and incident cardiac events (CHD and HF) were detected during a mean follow-up of 5.6 years. Alcohol consumption and serum levels of interleukin-6 (IL-6) and C-reactive protein (CRP) were assessed at baseline. Results: A total of 397 participants died, and 383 experienced an incident cardiac event. Compared with never or occasional drinkers, subjects drinking 1 to 7 drinks per week had lower age-, sex-, and race-adjusted incidences of death (27.4 vs 20.1 per 1000 person-years, respectively) and cardiac events (28.9 vs 20.8 per 1000 person-years). After adjustment for confounders, compared with never or occasional drinkers, light to moderate drinkers (1-7 drinks per week) showed a decreased risk of death (hazard ratio [HR], 0.75; 95% confidence interval [CI], 0.56-1.00) and cardiac events (HR, 0.72; CI, 0.54-0.97). Adjustment for potential mediators, and particularly inflammatory marker levels, did not affect the strength of this association. Conclusion: Light to moderate alcohol consumption was associated with significantly lower rates of cardiac events and longer survival, independent of its antiinflammatory effect.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Aged; Aging; Alcohol Drinking; Biomarkers; Body Composition; C-Reactive Protein; Female; Follow-Up Studies; Heart Diseases; Humans; Incidence; Inflammation; Interleukin-6; Male; Prognosis; Retrospective Studies; Risk Factors; Survival Rate; United States; Internal Medicine
Elenco autori:
C. Maraldi, S. Volpato, S.B. Kritchevsky, M. Cesari, E. Andresen, C. Leeuwenburgh, T.B. Harris, A.B. Newman, A. Kanaya, K.C. Johnson, N. Rodondi, M. Pahor
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