Fenofibrate attenuates cardiac and renal alterations in young salt-loaded spontaneously hypertensive stroke-prone rats through mitochondrial protection
Articolo
Data di Pubblicazione:
2018
Citazione:
Fenofibrate attenuates cardiac and renal alterations in young salt-loaded spontaneously hypertensive stroke-prone rats through mitochondrial protection / L. Castiglioni, A. Pignieri, F. Melania, M. Giudici, M. Crestani, N. Mitro, A. Mauro, Z. Carlamaria, R. Daniela, F. Claudia, F. Fabio, U. Guerrini, E. Tremoli, L. Sironi, P. Gelosa. - In: JOURNAL OF HYPERTENSION. - ISSN 0263-6352. - 36(2018), pp. 1129-1146. [10.1097/HJH.0000000000001651]
Abstract:
The simultaneous presence of cardiac and renal diseases is a pathological condition that leads to increased morbidity and mortality. Several lines of evidence have suggested that lipid dysmetabolism and mitochondrial dysfunction are pathways involved in the pathological processes affecting the heart and kidney. In the salt-loaded spontaneously hypertensive stroke-prone rat (SHRSP), a model of cardiac hypertrophy and nephropathy that shows mitochondrial alterations in the myocardium, we evaluated the cardiorenal effects of fenofibrate, a peroxisome proliferator-activated receptor alpha (PPARα) agonist that acts by modulating mitochondrial and peroxisomal fatty acid oxidation.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
L. Castiglioni, A. Pignieri, F. Melania, M. Giudici, M. Crestani, N. Mitro, A. Mauro, Z. Carlamaria, R. Daniela, F. Claudia, F. Fabio, U. Guerrini, E. Tremoli, L. Sironi, P. Gelosa
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