Data di Pubblicazione:
2017
Citazione:
Glycomimetics and Glycoconjugates as Therapeutics in Infectious Diseases / C. Colombo, A. Bernardi - In: Reference Module in Chemistry, Molecular Sciences and Chemical Engineering[s.l] : Elsevier, 2017 Oct 31. - ISBN 9780124095472. [10.1016/B978-0-12-409547-2.13887-9]
Abstract:
Mimics of natural carbohydrates (glycomimetics) and unnatural glycoconjugates are under intense scrutiny for the development of anti-infective therapies alternative or complementary to classical antibiotics. Three current approaches are reviewed in this article: (1) antiadhesive therapies, that focus on disrupting carbohydrate-protein complexes involved in microbial adhesion to host cells; (2) vaccines that use as antigens either polysaccharide fragments from bacterial and viruses surface or bacterial and viral lectins; (3) small molecule glycomimetic inhibitors of bacterial enzymes and antivirals.
Tipologia IRIS:
03 - Contributo in volume
Keywords:
glycomimetic; glycoconjugate; antiadhesive therapies; vaccine; antiviral; inhibitors; infectious diseases, lectin
Elenco autori:
C. Colombo, A. Bernardi
Link alla scheda completa:
Titolo del libro:
Reference Module in Chemistry, Molecular Sciences and Chemical Engineering