Data di Pubblicazione:
2017
Citazione:
Chronic Inflammation : Accelerator of Biological Aging / F. Bertrand, B. Eric, N. Fati, G. Sophie, M. Cesari. - In: THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. - ISSN 1758-535X. - 72:9(2017), pp. 1218-1225. [10.1093/gerona/glw240]
Abstract:
Biological aging is characterized by a chronic low-grade inflammation level. This chronic phenomenon has been named "inflamm-aging" and is a highly significant risk factor for morbidity and mortality in the older persons. The most common theories of inflamm-aging include redox stress, mitochondrial dysfunction, glycation, deregulation of the immune system, hormonal changes, epigenetic modifications, and dysfunction telomere attrition. Inflamm-aging plays a role in the initiation and progression of age-related diseases such as type II diabetes, Alzheimer's disease, cardiovascular disease, frailty, sarcopenia, osteoporosis, and cancer. This review will cover the identification of pathways that control age-related inflammation across multiple systems and its potential causal role in contributing to adverse health outcomes.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
aging; biology; chronic diseases; inflammation; Aging; Geriatrics and Gerontology
Elenco autori:
F. Bertrand, B. Eric, N. Fati, G. Sophie, M. Cesari
Link alla scheda completa: