Data di Pubblicazione:
2014
Citazione:
Forceps minor damage and co-occurrence of depression and fatigue in multiple sclerosis / C. Gobbi, M..A. Rocca, E. Pagani, G..C. Riccitelli, E. Pravatã , M. Radaelli, F. Martinelli-Boneschi, A. Falini, M. Copetti, G. Comi, M. Filippi. - In: MULTIPLE SCLEROSIS. - ISSN 1352-4585. - 20:12(2014), pp. 1633-1640.
Abstract:
Objective: Using diffusion tensor magnetic resonance imaging (DT MRI), we analyzed the architectural integrity of the brain white matter (WM) from a large cohort of MS patients to identify the structural substrates of the concomitant presence of depression and fatigue. Methods: Brain dual-echo, 3D T1-weighted and DT MRI scans were acquired from 147 MS patients and 90 gender- and age-matched healthy controls (HCs). Patients were stratified by the presence of depression (92 depressed (D), 55 not depressed (nD)) and fatigue (81 fatigued (F), 66 not fatigued (nF)). Sixty-five patients had co-occurrence of depression and fatigue (DF). Whole-brain voxel-wise comparisons of WM DT MRI abnormalities were performed using tract-based-spatial-statistics (TBSS). Tract-specific analyses were run in brain WM tracts using standard-space templates. Results: Whole-brain voxel-wise analysis yielded no significant differences between patient subgroups. At tract-specific analysis, DF patients had reduced fractional anisotropy (FA) of the forceps minor. Reduced FA of the right anterior thalamic radiation and right uncinate fasciculus was found in F-MS vs not F-MS patients after correcting for depression. No significant differences were found between D vs not D-MS patients, after correcting for fatigue. Conclusions: This study provides evidence for partially overlapping damage to frontal and fronto-temporal pathways underlying depression and fatigue in MS.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
depression; diffusion tensor magnetic resonance imaging; fatigue; forceps minor; Multiple sclerosis; regional damage; Adult; Aged; Depression; Depressive Disorder; Diffusion Tensor Imaging; Fatigue; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Multiple Sclerosis; Nerve Fibers, Myelinated; Nerve Net; Neurology; Neurology (clinical)
Elenco autori:
C. Gobbi, M..A. Rocca, E. Pagani, G..C. Riccitelli, E. Pravatã , M. Radaelli, F. Martinelli-Boneschi, A. Falini, M. Copetti, G. Comi, M. Filippi
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