Synthesis of L-tricholomic acid analogues and pharmacological characterization at ionotropic glutamate receptors
Articolo
Data di Pubblicazione:
2017
Citazione:
Synthesis of L-tricholomic acid analogues and pharmacological characterization at ionotropic glutamate receptors / L. Tamborini, F. Mastronardi, L. Lo Presti, B. Nielsen, C. De Micheli, P. Conti, A. Pinto. - In: CHEMISTRYSELECT. - ISSN 2365-6549. - 2:31(2017 Oct), pp. 10295-10299.
Abstract:
The synthesis of analogues of the natural compound ltricholomic acid and of its threo diastereoisomer was accomplished in order to explore their affinity for glutamate ionotropic receptors. In this study, fourteen new unnatural amino acids, characterized by a 3-hydroxy-~2 -isoxazoline or 3- hydroxy-~2 -pyrazoline-skeleton, were obtained exploiting, as key reaction, a 1,3-dipolar cycloaddition or an intramolecular cyclization.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
L. Tamborini, F. Mastronardi, L. Lo Presti, B. Nielsen, C. De Micheli, P. Conti, A. Pinto
Link alla scheda completa: