MFSD2A Promotes Endothelial Generation of Inflammation-resolving Lipid Mediators and Reduces Colitis in Mice
Articolo
Data di Pubblicazione:
2017
Citazione:
MFSD2A Promotes Endothelial Generation of Inflammation-resolving Lipid Mediators and Reduces Colitis in Mice / F. Ungaro, C. Tacconi, L. Massimino, P. Corsetto, C. Correale, P. Fonteyne, A. Piontini, V. Garzarelli, F. Calcaterra, S. Della Bella, A. Spinelli, M. Carvello, A. Rizzo, S. Vetrano, L. Petti, G. Fiorino, F. Furfaro, D. Mavilio, K. Maddipati, A. Malesci, L. Peyrin-Biroulet, S. D’Alessio, S. Danese. - In: GASTROENTEROLOGY. - ISSN 0016-5085. - 153:5(2017 Nov), pp. 1363-1377.e6. [10.1053/j.gastro.2017.07.048]
Abstract:
Alterations in signaling pathways that regulate resolution of inflammation (resolving pathways) contribute to pathogenesis of ulcerative colitis (UC). The resolution process is regulated by lipid mediators, such as those derived from the ω-3 docosahexaenoic acid (DHA), whose esterified form is transported by the major facilitator superfamily domain containing 2A (MFSD2A) through the endothelium of brain, retina, and placenta. We investigated if and how MFSD2A regulates lipid metabolism of gut endothelial cells to promote resolution of intestinal inflammation.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
IBD; angiogenesis; gut vasculature; inflammatory bowel disease
Elenco autori:
F. Ungaro, C. Tacconi, L. Massimino, P. Corsetto, C. Correale, P. Fonteyne, A. Piontini, V. Garzarelli, F. Calcaterra, S. Della Bella, A. Spinelli, M. Carvello, A. Rizzo, S. Vetrano, L. Petti, G. Fiorino, F. Furfaro, D. Mavilio, K. Maddipati, A. Malesci, L. Peyrin-Biroulet, S. D’Alessio, S. Danese
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