Data di Pubblicazione:
2017
Citazione:
The 1,2,3-triazole ring as a bioisostere in medicinal chemistry / E. Bonandi, M.S. Christodoulou, G. Fumagalli, D. Perdicchia, G. Rastelli, D. Passarella. - In: DRUG DISCOVERY TODAY. - ISSN 1359-6446. - 22:10(2017 Oct), pp. 1572-1581.
Abstract:
1,2,3-Triazole is a well-known scaffold that has a widespread occurrence in different compounds characterized by several bioactivities, such as antimicrobial, antiviral, and antitumor effects. Moreover, the structural features of 1,2,3-triazole enable it to mimic different functional groups, justifying its wide use as a bioisostere for the synthesis of new active molecules. Here, we provide an overview of the 1,2,3-triazole ring as a bioisostere for the design of drug analogs, highlighting relevant recent examples.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Pharmacology; Drug Discovery; 3003; Pharmaceutical Science
Elenco autori:
E. Bonandi, M.S. Christodoulou, G. Fumagalli, D. Perdicchia, G. Rastelli, D. Passarella
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