Efficacy and safety of nabiximols (Sativex®) on multiple sclerosis spasticity in a real-life Italian monocentric study
Articolo
Data di Pubblicazione:
2016
Citazione:
Efficacy and safety of nabiximols (Sativex®) on multiple sclerosis spasticity in a real-life Italian monocentric study / L. Ferré, A. Nuara, G. Pavan, M. Radaelli, L. Moiola, M. Rodegher, B. Colombo, I.J. KELLER SARMIENTO, V. Martinelli, L. Leocani, F. Martinelli Boneschi, G. Comi, F. Esposito. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-1874. - 37:2(2016), pp. 235-242. [10.1007/s10072-015-2392-x]
Abstract:
Multiple sclerosis (MS) patients frequently suffer from limb spasticity and pain despite antispastic treatments. To investigate nabiximols efficacy and safety in a real-world monocentric Italian cohort, the following data were collected at baseline, week 4, 14 and 48: Ambulation Index (AI), 10-min walking test (10MWT), combined Modified Ashworth scale (cMAS), scores at numerical rating scale for spasticity (sNRS) and pain (pNRS). Responder status was defined as a ≥20 % reduction in sNRS after 4 weeks of treatment. 144 MS patients (123 progressive and 21 relapsing-remitting) complaining of moderate-to-severe spasticity (mean sNRS: 7.5) were included: 138 (95.8 %) completed the first month of therapy and were classified as follows-23.2 % were non-responders, 5.1 % were responders but discontinued treatment due to side effects, 71.7 % were responders with a mean 32 % reduction in sNRS (p < 0.001). In responders sNRS further decreased between 4 and 14 weeks (p = 0.03). Similarly, pNRS improvement was seen during the first month and between 4 and 14 weeks (p < 0.001 and p = 0.004, respectively). Moreover, at 4 weeks responders showed a significant (p < 0.05) improvement in cMAS, AI and 10MWT, which was maintained at 14 weeks. At 1-year follow-up, a benefit was still evident on spasticity and painful symptoms with a low drop-out rate. Confusion/ideomotor slowing, fatigue and dizziness were the most frequent side effects; no major adverse events were reported. Shorter disease duration at treatment start was associated with better response. This real-world study confirms nabiximols efficacy and safety in the treatment of MS-related spasticity and pain, which is maintained up to 48 weeks.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Multiple sclerosis; Nabiximols; Pain; Spasticity; Adult; Cannabidiol; Cohort Studies; Dronabinol; Drug Combinations; Female; Humans; Italy; Male; Middle Aged; Multiple Sclerosis; Muscle Spasticity; Severity of Illness Index; Treatment Outcome; 2708; Neurology (clinical); Psychiatry and Mental Health
Elenco autori:
L. Ferré, A. Nuara, G. Pavan, M. Radaelli, L. Moiola, M. Rodegher, B. Colombo, I.J. KELLER SARMIENTO, V. Martinelli, L. Leocani, F. Martinelli Boneschi, G. Comi, F. Esposito
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