Data di Pubblicazione:
2014
Citazione:
Familial clustering in Italian progressive-onset and bout-onset multiple sclerosis / C. Guaschino, F. Esposito, G. Liberatore, B. Colombo, P. Annovazzi, E. D'Amico, P. Cavalla, E. Capello, R. Capra, D. Galimberti, G. Tedeschi, L. Grimaldi, M. Leone, S. D'Alfonso, V. Martinelli, G. Comi, F. Martinelli-Boneschi. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-1874. - 35:5(2014), pp. 789-791. [10.1007/s10072-014-1650-7]
Abstract:
Multiple sclerosis (MS) is a complex disease triggered by environmental and genetic agents, and clinically characterized by bout onset (BOMS) or progressive onset (PrMS). We collected clinical and familial aggregation data in a cohort of 518 Italian PrMS patients, and compared with 400 BOMS cases. An increased prevalence of MS in first-degree relatives of Italian PrMS was found. Familial aggregation is not influenced by probands' clinical course, and there is no disease course concordance within MS families. These data are useful in counseling MS patients affected with different clinical courses of the disease.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Multiple sclerosis; Progressive; Recurrence risk; Relapsing-remitting; Adult; Aged; Aged, 80 and over; Cluster Analysis; Disease Progression; Humans; Italy; Male; Middle Aged; Multiple Sclerosis; Prevalence; Young Adult; Family; Genetic Predisposition to Disease; Phenotype; 2708; Neurology (clinical); Psychiatry and Mental Health
Elenco autori:
C. Guaschino, F. Esposito, G. Liberatore, B. Colombo, P. Annovazzi, E. D'Amico, P. Cavalla, E. Capello, R. Capra, D. Galimberti, G. Tedeschi, L. Grimaldi, M. Leone, S. D'Alfonso, V. Martinelli, G. Comi, F. Martinelli-Boneschi
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