Data di Pubblicazione:
2017
Citazione:
Captopril does not Potentiate Post-Exercise Hypotension : a Randomized Crossover Study / A.C.C. Queiroz, J.C.S. Sousa, N.D. Silva, E. Tobaldini, K.C. Ortega, E.M. De Oliveira, P.C. Brum, N. Montano, D. Mion, T. Tinucci, C.L. De Moraes Forjaz. - In: INTERNATIONAL JOURNAL OF SPORTS MEDICINE. - ISSN 0172-4622. - 38:4(2017), pp. 270-277. [10.1055/s-0042-123044]
Abstract:
To evaluate whether captopril (3×50 mg/day) potentiates post-resistance exercise hypotension (PREH) in hypertensives (HT), 12 HT men received captopril and placebo for 4 weeks each in a double-blinded, randomized-crossover design. On each therapy, subjects underwent 2 sessions: Control (C - rest) and Resistance Exercise (RE - 7 exercises, 3 sets to moderate fatigue, 50% of 1 RM -repetition maximum). Measurements were taken before and after 30-60 min (Post1) and 7 h (Post2), and ambulatory blood pressure (BP) was monitored for 24 h. There were no differences in PREH characteristics and mechanisms between the placebo and captopril periods. At Post1, systolic/diastolic BP decreased significantly and similarly after RE with both therapies (Placebo=-13±2/-9±1 mmHg vs. Captopril=-12±2/-10±1 mmHg, P<0.05). RE reduced cardiac output in some subjects and systemic vascular resistance in others. Heart rate and cardiac sympathetic modulation increased, while stroke volume and baroreflex sensitivity decreased after RE (Placebo: +13±2 bpm, +21±5 nu, -11±5 ml, -4±2 ms/mmHg; Captopril: +13±2 bpm, +35±4 nu, 17±5 ml, -3±1 ms/mmHg, P<0.05). At Post2, all variables returned to pre-intervention values. Ambulatory BP was similar between the sessions. Thus, captopril did not potentiate the magnitude and duration of PREH in HT men, and it did not influence PREH mechanisms.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
angiotensin I-converting enzyme inhibitor; autonomic modulation; blood pressure; hypertension; placebo-controlled; strength exercise; Antihypertensive Agents; Blood Pressure; Captopril; Cross-Over Studies; Double-Blind Method; Heart Rate; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Post-Exercise Hypotension; Stroke Volume; Vascular Resistance; Resistance Training; Orthopedics and Sports Medicine
Elenco autori:
A.C.C. Queiroz, J.C.S. Sousa, N.D. Silva, E. Tobaldini, K.C. Ortega, E.M. De Oliveira, P.C. Brum, N. Montano, D. Mion, T. Tinucci, C.L. De Moraes Forjaz
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