Efficacy of Statin Therapy in Pulmonary Arterial Hypertension : a Systematic Review and Meta-Analysis
Articolo
Data di Pubblicazione:
2016
Citazione:
Efficacy of Statin Therapy in Pulmonary Arterial Hypertension : a Systematic Review and Meta-Analysis / M. Rysz Górzynska, A. Gluba Brzózka, A. Sahebkar, M. Serban, D.P. Mikhailidis, S. Ursoniu, P.P. Toth, V. Bittner, G.F. Watts, G.Y.H. Lip, J. Rysz, A.L. Catapano, M. Banach. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 6:1(2016), pp. 30060.1-30060.10. [10.1038/srep30060]
Abstract:
Since the evidence regarding statin therapy in PAH has not been conclusive, we assessed the impact of statin therapy in PAH through a systematic review and meta-analysis of available studies. We searched selected databases up to August 1, 2015 to identify the studies investigating the effect of statin administration on PAH. Meta-analysis was performed using either a fixed-effects or random-effect model according to I 2 statistic. Meta-analysis of 8 studies with 665 patients did not suggest any significant improvement in 6-min walking distance (6MWD) by statin therapy (weighed mean difference [WMD]:-6.08 m, 95% confidence interval [CI]:-25.66, 13.50, p = 0.543; Q = 8.41, I 2 = 28.64%). Likewise, none of the other indices including pulmonary arterial pressure (WMD:-0.97 mmHg, 95%CI:-4.39, 2.44, p = 0.577; Q = 14.64, I 2 = 79.51%), right atrial pressure (WMD: 1.01 mmHg, 95%CI:-0.93, 2.96, p = 0.307; Q = 44.88, I2 = 95.54%), cardiac index (WMD: 0.05 L/min/m2, 95%CI:-0.05, 0.15, p = 0.323; Q = 3.82, I 2 = 21.42%), and pulmonary vascular resistance (WMD:-1.42 dyn∗s/cm5, 95%CI:-72.11, 69.27, p = 0.969; Q = 0.69, I2 = 0%) was significantly altered by statin therapy. In conclusion, the results of the meta-analysis did not show a statistically significant effect of statin therapy in the improvement of 6MWD, pulmonary arterial pressure, right atrial pressure, cardiac index and pulmonary vascular resistance.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Multidisciplinary
Elenco autori:
M. Rysz Górzynska, A. Gluba Brzózka, A. Sahebkar, M. Serban, D.P. Mikhailidis, S. Ursoniu, P.P. Toth, V. Bittner, G.F. Watts, G.Y.H. Lip, J. Rysz, A.L. Catapano, M. Banach
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