Data di Pubblicazione:
2017
Citazione:
Cytotoxic and Antimicrobial Activities of Cantharellus cibarirrs Fr. (Cantarellaceae) / M. Kolundzic, T. Stanojkovic, J. Radovic, A. Tacic, M. Dodevska, M. Milenkovic, F. Sisto, C. Masia, G. Farronato, V. Nikolic, T. Kundakovic. - In: JOURNAL OF MEDICINAL FOOD. - ISSN 1096-620X. - 20:8(2017 Aug), pp. 790-796. [10.1089/jmf.2016.0176]
Abstract:
Antibacterial and cytotoxic activities of cyclohexane, dichloromethane, methanol, and aqueous extracts of
Cantharellus cibarius were tested. Broth microdilution assay was performed against 10 bacterial strains (Staphylococcus
aureus, S. epidermidis, Micrococcus luteus, Bacillus subtilis, Enterococcus feacalis, Escherichia coli, Klebsiella pneumoniae,
Pseudomonas aeruginosa, Salmonella abony), with emphasis on Helicobacter pylori. Methanol extract was the most active
against H. pylori strains with minimal inhibitory concentration values between 4 and 32 µg/mL. All extracts were active
against antibiotic resistant H. pylori. Methanol and aqueous extracts had no cytotoxicity against tested cell lines, whereas
cyclohexane and dichloromethane extracts were active against HeLa and N87 cells, but also against healthy MRC-5 cells (IC50
39.26 ±1.24–134.79 ± 0.01 µg/mL). The tested aqueous extracts have shown 68% of angiotensin-converting enzyme inhibitory
activity in doses of 1.25 mg/mL. Chemical analysis has shown the presence of linoleic, cis-vaccenic, and oleic acids, sterols,
b-glucans, and polyphenolic compounds.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
antibacterìal activìly; ACE inhibitory activìty; beta-glucan; Cantharellus cibarius; cytotoxicity.
Elenco autori:
M. Kolundzic, T. Stanojkovic, J. Radovic, A. Tacic, M. Dodevska, M. Milenkovic, F. Sisto, C. Masia, G. Farronato, V. Nikolic, T. Kundakovic
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