Synthesis of Enantiomerically Enriched 2-Hydroxymethylalkanoic Acids by Oxidative Desymmetrisation of Achiral 1,3-Diols Mediated by Acetobacter aceti
Articolo
Data di Pubblicazione:
2016
Citazione:
Synthesis of Enantiomerically Enriched 2-Hydroxymethylalkanoic Acids by Oxidative Desymmetrisation of Achiral 1,3-Diols Mediated by Acetobacter aceti / E. Brenna, F. Cannavale, M. Crotti, V. De Vitis, F.G. Gatti, G. Migliazza, F. Molinari, F. Parmeggiani, D. Romano, S. Santangelo. - In: CHEMCATCHEM. - ISSN 1867-3880. - 8:24(2016 Dec 19), pp. 3796-3803. [10.1002/cctc.201601051]
Abstract:
The stereoselective desymmetrisation of achiral 2-alkyl-1,3-diols is performed by oxidation of one of the two enantiotopic primary alcohol moieties by means of Acetobacter aceti MIM 2000/28 to afford the corresponding chiral 2-hydroxymethyl alkanoic acids (up to 94 % ee). The procedure, carried out in aqueous medium under mild conditions of pH, temperature and pressure, contributes to enlarge the portfolio of enzymatic oxidations available to organic chemists for the development of sustainable manufacturing processes.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
acetic acid bacteria; biocatalysis; desymmetrization; enantioselectivity; oxidation; catalysis; physical and theoretical chemistry; organic chemistry; inorganic chemistry
Elenco autori:
E. Brenna, F. Cannavale, M. Crotti, V. De Vitis, F.G. Gatti, G. Migliazza, F. Molinari, F. Parmeggiani, D. Romano, S. Santangelo
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