Data di Pubblicazione:
2017
Citazione:
Glyco-functionalized dinuclear rhenium(i) complexes for cell imaging / A. Palmioli, A. Aliprandi, D. Septiadi, M. Mauro, A. Bernardi, L. De Cola, M. Panigati. - In: ORGANIC & BIOMOLECULAR CHEMISTRY. - ISSN 1477-0520. - 15:7(2017), pp. 1686-1699.
Abstract:
The design, synthesis and photophysical characterization of four new luminescent glycosylated luminophores
based on dinuclear rhenium complexes, namely Glyco-Re, are described. The derivatives have the
general formula [Re2(μ-Cl)2(CO)6(μ-pydz-R)] (R-pydz = functionalized 1,2-pyridazine), where a sugar
residue (R) is covalently bound to the pyridazine ligand in the β position. Different synthetic pathways have
been investigated including the so-called neo-glycorandomization procedure, affording stereoselectively
glyco-conjugates containing glucose and maltose in a β anomeric configuration. A multivalent dinuclear
rhenium glycodendron bearing three glucose units is also synthesized. All the Glyco-Re conjugates are
comprehensively characterized and their photophysical properties and cellular internalization experiments
on human cervical adenocarcinoma (HeLa) cells are reported. The results show that such Glyco-Re
complexes display interesting bio-imaging properties, i.e. high cell permeability, organelle selectivity, low
cytotoxicity and fast internalization. These findings make the presented Glyco-Re derivatives efficient
phosphorescent probes suitable for cell imaging application
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
A. Palmioli, A. Aliprandi, D. Septiadi, M. Mauro, A. Bernardi, L. De Cola, M. Panigati
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